Table 4.
Predictors of early treatment response in HLH patients.
| Univariate analysis | Multivariate analysis | |||
|---|---|---|---|---|
| OR (95%CI) | p-value | OR (95%CI) | p-value | |
| No CNS involvement | 6.5 (2.2–19.4) | 0.001* | 6.6 (1.5–28.8) | 0.011* |
| Platelet ≥ 44 × 106/mm3 | 6.2 (2.2–17.3) | 0.001* | 8 (2.1–30.9) | 0.003* |
| PTT ≤ 35 sa | 3 (1.1–8.1) | 0.031* | 1.6 (0.4–6.6) | 0.481 |
| Total bilirubin ≤ 1.8 mg/d | 6.6 (2.3–18.6) | <0.001* | 4 (1.1–14.8) | 0.036* |
HLH, hemophagocytic lymphohistiocytosis; CNS, central nervous system; PTT, partial thromboplastin time; OR, odds ratio; CI, confidence interval. *p <0.05 was considered statistically significant. apatients with early treatment response (n = 46), patients without early treatment response (n = 26).