Table 2.
Univariable and multivariable analyses of factors associated with OS in the 83 patients with hepatocholangiocarcinoma
| Variables | Univariable cox regression |
Multivariable cox regression* |
||||||
|---|---|---|---|---|---|---|---|---|
| HR | 2.5 | 97.5 | pvalue | HR | 2.5 | 97.5 | pvalue | |
| Male | 1.79 | 1.05 | 3.03 | 0.032 | 1.12 | 0.59 | 2.13 | 0.731 |
| Age (years) | 1.00 | 0.98 | 1.02 | 0.927 | ||||
| Hepatitis B virus | 0.76 | 0.41 | 1.40 | 0.370 | ||||
| Hepatitis C virus | 1.06 | 0.56 | 2.03 | 0.846 | ||||
| Metabolic syndrome | 1.32 | 0.82 | 2.12 | 0.247 | ||||
| BMI (kg/m2) | 1.00 | 0.96 | 1.05 | 0.911 | ||||
| Arterial hypertension | 1.12 | 0.71 | 1.79 | 0.615 | ||||
| Dyslipidemia | 1.35 | 0.85 | 2.14 | 0.207 | ||||
| Tobacco | 2.29 | 1.40 | 3.74 | 0.001 | 2.29 | 1.08 | 4.87 | 0.032 |
| Alcohol intake | 2.17 | 1.26 | 3.73 | 0.006 | 0.91 | 0.44 | 1.89 | 0.804 |
| Diabetes | 1.33 | 0.83 | 2.13 | 0.229 | ||||
| Ascites | 4.64 | 1.68 | 12.80 | 0.004 | 3.45 | 1.31 | 9.03 | 0.013 |
| Encephalopathy | 4.94 | 0.38 | 64.66 | 0.207 | ||||
| PS grade | ||||||||
| 0 | Ref | Ref | Ref | Ref | Ref | Ref | Ref | Ref |
| 1 | 0.74 | 0.41 | 1.33 | 0.305 | 0.92 | 0.46 | 1.84 | 0.805 |
| 2 | 2.84 | 0.86 | 9.42 | 0.081 | 1.59 | 0.57 | 4.49 | 0.360 |
| 3 | 2.21 | 0.27 | 18.12 | 0.433 | 12.49 | 0.07 | 22.47 | 0.273 |
| AFP | 1.00 | 1.00 | 1.00 | 0.281 | ||||
| CA19-9 | 1.00 | 1.00 | 1.00 | 0.249 | ||||
| Unique tumor(s) | 0.81 | 0.49 | 1.32 | 0.394 | ||||
| Size of the biggest nodule | 1.00 | 0.99 | 1.01 | 0.947 | ||||
| Sum of tumor(s) diameter | 1.00 | 0.99 | 1.01 | 0.823 | ||||
| Macrovascular invasion | 1.26 | 0.76 | 2.08 | 0.360 | ||||
| Metastasis | 1.04 | 0.63 | 1.73 | 0.872 | ||||
| Previous treatment | 0.80 | 0.50 | 1.27 | 0.334 | ||||
| First-line regimen | ||||||||
| Platinum-based | Ref | Ref | Ref | Ref | ||||
| TKI | 1.04 | 0.63 | 1.73 | 0.87 | ||||
| MELD score | 1.07 | 0.98 | 1.17 | 0.124 | 1.09 | 0.97 | 1.22 | 0.138 |
| ALBI grade | 2.20 | 1.24 | 3.91 | 0.010 | 2.15 | 1.23 | 3.76 | 0.009 |
| Advanced fibrosis | 1.43 | 0.88 | 2.33 | 0.144 | 1.12 | 0.61 | 2.06 | 0.711 |
BMI, body mass index; AFP, alpha-fetoprotein; CA19-9, carbohydrate antigen 19-9; TKI, tyrosine kinase inhibitor; PS, performance status; MELD, Model for End-Stage Liver Disease; ALBI, albumin-bilirubin score.
*
Variables included in the multivariable Cox model were selected based on the results of the univariable analysis (i.e., all variables associated to OS with a p value <0.200).