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. 2022 Mar 9;14(5):393–417. doi: 10.1159/000522331

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Copyright © 2022 by The Author(s). Published by S. Karger AG, Basel

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Fig. 5 — a, bAbnormal NET presence is associated with cardiovascular disease. With the progression of atherosclerosis, migration of neutrophils to the site of microinjury can be observed. The accumulation of neutrophils and NETs may serve as a scaffold facilitating thrombogenesis, for instance via the action of histones H3 and H4. Over time, this may eventually lead to vein occlusion. NET, neutrophil extracellular trap.