Skip to main content
. 2022 Mar 9;14(5):393–417. doi: 10.1159/000522331

Fig. 6.

Fig. 6

Changes in the brain leading to demyelination and axon damage. Citrullination normally occurs also in the brain; however, the percentage amount of citrullinated proteins such as MBP, GFAP, or MOG is associated with the severity of MS. Via citrullination, new epitopes are formed which leads to neutrophil infiltration, NET formation, demyelination of the myelin sheath, and ultimately, failure in signal transduction causing, and ever-increasing degree of disability. GFAP, glial acidic fibrillary protein; MBP, myelin basic protein; MOG, myelin oligodendrocyte glycoprotein; MS, multiple sclerosis; NET, neutrophil extracellular trap.