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. 2022 Jan 28;14(5):502–517. doi: 10.1159/000521633

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Copyright © 2022 by The Author(s). Published by S. Karger AG, Basel

This article is licensed under the Creative Commons Attribution-NonCommercial 4.0 International License (CC BY-NC). Usage and distribution for commercial purposes requires written permission. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

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Fig. 2 — Characteristics of renal I/R with Candida administration (I/R fungi) or I/R PBS or sham with Candida administration (Sham fungi) at 24 h after surgery as determined by systemic inflammatory responses as indicated by serum cytokines (TNF-α, IL-6, IL-10, and IL-1β) (a–d) and NETs formation as evaluated by serum dsDNA (e) and in peripheral blood neutrophils using gene expression of PAD4 (f), cell morphology in DAPI staining (blue color) (g), co-staining of MPO and NE (h), with the representative pictures of DAPI staining (original magnification, ×200) (i, upper part) and immunofluorescence of MPO/NE (original magnification, ×630) (i, lower part) are demonstrated (n = 6–7/group). Notably, the sham group without Candida administration is not demonstrated due to the similarity to sham with Candida (normal values in all parameters).