. Author manuscript; available in PMC: 2023 Mar 1.

Published in final edited form as: Wiley Interdiscip Rev Nanomed Nanobiotechnol. 2021 Aug 19;14(2):e1752. doi: 10.1002/wnan.1752

Table 1:

Cytokine-based immunotherapy via dendrimer nanoparticles

Dendrimer	Surface group/Ligand	Cytokine- expressing Immune Cell	Cytokine	Ref.
PAMAM-NH₂ G5	IL-3	-	IL-3↑	Lee 2004
PAMAM-NH₂ G5	pTRAIL	-	TRAIL↑	Han 2011; Huang 2011; Gao 2015
Dendrigraft poly-L-lysine G3	pTRAIL	-	TRAIL↑	Li 2013
PAMAM-NH₂ G4	pIL-2	-	IL-2↑	Huang 2020
Polyman26	mannose	DC	β-chemokine↑, IL-1β↑, IL-6↑, IL-12↑, TNFα↑	Berzi 2016
carbosilane (2G-03NN24)	-	macrophage	M1 polarization↑, M2 polarization↓	Perisé-Barrios 2015

MDDC: monocytes-derived dendritic cells; TAM: tumor-associated macrophages; PBMC: peripheral blood mononuclear cells; MDM: monocytederived macrophages; DC: dendritic cells.