TABLE 1.
Ten most negatively correlated small-molecule compounds screened from the CMap database.
| Score | CMap name | Target | MOA |
|---|---|---|---|
| −96.37 | Calyculin | PPP1CA, PPP1CC, and PPP2CA | Protein phosphatase inhibitor |
| −96.48 | TG-101348 | JAK2, FLT3, BRD4, JAK1, JAK3, RET, TYK2 | FLT3 inhibitor, JAK inhibitor |
| −96.93 | AZD-7762 | CHEK1, and CHEK2 | CHK inhibitor |
| −97.18 | CS-110266 | SLC6A3 | Dopamine receptor agonist |
| −97.42 | PI-828 | PI3K inhibitor | |
| −97.6 | PI-103 | PIK3CA, PIK3CG, MTOR, PIK3CB, PIK3CD, and PRKDC | MTOR inhibitor, PI3K inhibitor |
| −97.71 | RO-90-7501 | APP | Beta amyloid inhibitor |
| −97.77 | Naftopidil | ADRA1A and ADRA1D | Adrenergic receptor antagonist |
| −97.8 | PJ-34 | EEF2, PARP1, PARP15, and PARP3 | PARP inhibitor |
| −98.41 | ZSTK-474 | PIK3CG, PIK3CA, PIK3CB, and PIK3CD | PI3K inhibitor |
MOA: Mechanisms of action.