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. 2022 Sep 5;65:101590. doi: 10.1016/j.molmet.2022.101590

Figure 2.

Figure 2

Portal GLP-1 is sensitive to capsaicin-deafferentation. Chow-fed Syrian golden hamsters were deafferented via IP capsaicin injection (see methods). Two weeks later hamsters underwent OGTT and ITT (n = 12/group) (F-I), then on the third week hamsters were fasted for 16 h and vehicle-treated (Veh_XX) or capsaicin-treated (CAP_XX) hamsters received portal vein injections of GLP-1(7-36) (10 μg/kg) or vehicle (PBS). Hamsters were then fat loaded via an oral gavage of olive oil (200 μl) and received IP Pluronic F-127 (2  g/kg). Blood was drawn over a 6 h period via retro-orbital bleeds. (A) Baseline plasma TG, (B) baseline plasma cholesterol, (C) food consumption, (D) body weight, (E) 2-week fasting blood glucose, (F) OGTT, (G) OGTT AUC, (H) ITT, (I) ITT AUC, (J) plasma TG, (K) plasma TG AUC, (L) plasma cholesterol, (M) plasma cholesterol AUC (N) TRL TG, (O) TRL TG AUC, (P) TRL cholesterol, (Q) TRL cholesterol AUC. Data is presented as means ± SEM (n=6/group). (∗P < 0.05, ∗∗P < 0.01, ∗∗∗P < 0.001). ∗; Veh_Veh vs. Veh_GLP-1, ˆ; Veh_GLP-1 vs. CAP_Veh, @; Veh_GLP-1 vs. CAP_GLP-1.