Skip to main content
. 2022 Sep 5;65:101590. doi: 10.1016/j.molmet.2022.101590

Figure 3.

Figure 3

Selective vagal denervation of GLP-1R-containing neurons results in elevated postprandial blood lipids. Chow-fed Syrian golden hamsters received bilateral nodose ganglia injections of Exenatide-Saponin (SAP) (1ug in 1 μl), or a blank scramble protein linked to Saponin (Blank). Two weeks later hamsters were fasted for 16 h then received an oral gavage of olive oil (200 μl) and were injected with IP Pluronic F-127 (2  g/kg). Blood was collected over a 6 h period via retro-orbital bleeds. (A) 2-week fasting plasma TG, (B) 2-week fasting plasma cholesterol, (C) food consumption, (D) body weight change (E) plasma TG, (F) plasma TG AUC, (G) plasma cholesterol, (H) plasma cholesterol AUC, (I) TRL TG, (J) TRL TG AUC, (K) TRL cholesterol, (L) TRL cholesterol AUC. Data is presented as means ± SEM (n=5/group). (∗P < 0.05, ∗∗P < 0.01).