Skip to main content
. 2022 Sep 5;65:101590. doi: 10.1016/j.molmet.2022.101590

Figure 4.

Figure 4

Selective vagal denervation of GLP-1R-containing neurons abrogates the portal GLP-1 effect. Chow-fed Syrian golden hamsters received bilateral nodose ganglia injections of Exenatide-Saponin (SAP) (1ug in 1 μl), or a blank scramble protein linked to Saponin (Blank). Two weeks later hamsters were fasted overnight and then Blank-treated (Blank_XX) or Saponin-treated (SAP_XX) hamsters received a portal vein injection of either GLP-1(7-36) (10 μg/kg) or vehicle (PBS). Hamsters were then fat loaded with an oral gavage of olive oil (200 μl) and given an IP injection of Pluronic F-127 (2  g/kg). Blood was drawn over a 6 h period via retro-orbital bleeds. (A) 2-week fasting plasma TG, (B) 2-week fasting plasma cholesterol, (C) food consumption, (D) body weight change, (E) Organ weight, (F) ITT, (G) ITT AUC, (H) Plasma TG, (I) plasma TG AUC, (J) plasma cholesterol, (K) plasma cholesterol AUC, (L) TRL TG, (M) TRL TG AUC, (N) TRL cholesterol, (O) TRL cholesterol AUC. Data is presented as means ± SEM (A-G: n = 10/group; H-O: n = 5/group). (∗P < 0.05, ∗∗P < 0.01). ∗; Blank_Veh vs. Blank_GLP-1, ˆ; SAP_Veh vs. Blank_GLP-1, $; SAP_GLP-1 vs. Blank_GLP-1.