Figure 1.

The transcriptional and genetic features of 25 RNA modification writers in LUAD (TCGA cohort). (a) 131 of 355 LUAD patients had genetic alterations of the above writers. The fraction of every variant type was presented in the right bar graph and the proportion of conversions was presented in the bottom bar graph. (b) The CNV mutation features of 25 RNA modification writers were shown in the bar graph. CNV loss referred to hemizygous and homozygous deletion, CNV gain referred to gain and high-level amplification. (c) Classification of cancer and normal samples via the principal component analysis of 25 RNA modification writers. (d) The Spearman correlation analysis among the 25 RNA modification writers. *P < 0.05, **P < 0.01, and ***P < 0.001. (e-h) The expression distribution of four kinds of RNA modification writers (m¹A, m⁶A, A-I and APA) between tumor and normal samples.