Figure 4.

The construction and evaluation of the Writer-Score model. (a) The alluvial diagram of different clusters with various GSE groups, DEGclusters and Writer-Score groups. (b) The distribution diagram of Writer-Score in three distinct clusters. *P < 0.05; **P < 0.01; ***P < 0.001. (c) The distribution diagram of Writer-Score in two distinct DEGclusters. (d) LASSO regression was applied to establish the Writer-Score model. (e-h) The Kaplan-Meier curves of high and low Writer-Score patients and their time-dependent ROC curves in meta-GEO, TCGA, GSE72094 and GSE13213 cohorts (Log-rank test). (i) The comparison of the tumor mutation burden (TMB) between high and low Writer-Score patients in the TCGA cohort. (j-k) Mutational landscape of the top mutational genes between high and low Writer-Score groups in the TCGA cohort. The upper bar plot referred to the annotations, including stage, Nstage and Tstage.