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. 2022 Sep 6;9:999315. doi: 10.3389/fcvm.2022.999315

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Copyright © 2022 Merbach, Ramchandran and Spearman.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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sVEGFR1 is not significantly expressed by hepatocytes in the liver. (A,A') Immunohistochemistry of mouse liver demonstrates strong staining in the sinusoidal regions of the liver with negligible staining in hepatocytes; scale bar 50 μm. (B,B') RNAscope of mouse liver demonstrates hybridization signal in the sinusoidal regions of the liver; scale bar 50 μm. (C) Quantitative RT-PCR of isolated hepatocytes and non-parenchymal cells (NPCs) shows significantly greater expression of Vegfr1 in NPCs compared to hepatocytes; n = 3 wild-type mice and supporting gene expression patterns to confirm isolation of pure cell populations. Analysis with paired t-tests.