Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2022 Sep 19;221(10):e202208008. doi: 10.1083/jcb.202208008

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2022 Barros-Carvalho and Morais-de-Sa

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms/). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 International license, as described at https://creativecommons.org/licenses/by-nc-sa/4.0/).

PMC Copyright notice

Figure 1. — PP1 regulates PAR-2 asymmetry in the one-cell C. elegans embryo. An overview of PAR-2 localization in genetic modifications presented in Calvi et al. (2) is shown on top. A model to generate an anterior–posterior asymmetry of phosphorylated PAR-2 based on uniform PP1 activity counterbalancing asymmetric PKC-3 is shown at the bottom. Binding of the degenerate RVxF motif of PAR-2 to PP1 may collaborate with microtubule-dependent protection from PKC-3 phosphorylation to promote cortical loading of PAR-2 at the posterior (close-up). BH, Basic-and-Hydrophobic motif.