Table 6.
Effect size of MAP on diabetes in prespecified and exploratory subgroups
| Characteristic | Participants | HR (95% CI) P value for interaction |
| Age (years) | <0.001 | |
| 20 to <30 | 28 597 | 1.000 (0.973 to 1.028) 0.985 |
| 30 to <40 | 82 782 | 1.021 (1.011 to 1.030)<0.001 |
| 40 to <50 | 45 093 | 1.012 (1.005 to 1.019) 0.001 |
| 50 to <60 | 29 609 | 1.006 (1.001 to 1.012) 0.020 |
| 60 to <70 | 17 271 | 1.001 (0.995 to 1.008) 0.658 |
| ≥70 | 7066 | 0.999 (0.991 to 1.007) 0.881 |
| Gender | 0.085 | |
| Male | 115101 | 1.005 (1.002 to 1.009) 0.003 |
| Female | 95 317 | 1.011 (1.006 to 1.016)<0.001 |
| BMI (kg/m2) | 0.943 | |
| <18.5 | 12 066 | 0.997 (0.958 to 1.038) 0.892 |
| ≥18.5,<24 | 116 485 | 1.008 (1.002 to 1.014) 0.005 |
| ≥24,<28 | 64 156 | 1.009 (1.004 to 1.013)<0.001 |
| ≥28 | 17 711 | 1.007 (1.001 to 1.014) 0.015 |
| FPG (mmol/L) | <0.001 | |
| <6.1 | 203 401 | 1.016 (1.012 to 1.020)<0.001 |
| ≥6.1 | 7017 | 0.999 (0.994 to 1.003) 0.603 |
| HDL-C (mmol/L) | 0.242 | |
| Low | 38 534 | 1.009 (1.003 to 1.015) 0.003 |
| Medium | 37 978 | 0.999 (0.992 to 1.005) 0.686 |
| High | 39 906 | 1.005 (0.998 to 1.012) 0.204 |
| Not recorded | 94 000 | 1.011 (1.006 to 1.017)<0.001 |
| LDL-C (mmol/L) | 0.523 | |
| Low | 38 867 | 1.009 (1.002 to 1.016) 0.016 |
| Medium | 39 173 | 1.006 (0.999 to 1.013) 0.082 |
| High | 39 504 | 1.002 (0.996 to 1.008) 0.505 |
| Not recorded | 92 874 | 1.012 (1.006 to 1.017)<0.001 |
| Smoking status | 0.188 | |
| Current smoker | 11 977 | 1.008 (0.998 to 1.018) 0.138 |
| Ever smoker | 2546 | 1.040 (1.014 to 1.066) 0.002 |
| Never smoker | 45 398 | 1.015 (1.007 to 1.023)<0.001 |
| Not recorded | 150 497 | 1.006 (1.003 to 1.010)<0.001 |
| Drinking status | 0.047 | |
| Current drinker | 1329 | 1.029 (0.998 to 1.060) 0.063 |
| Ever drinker | 8911 | 1.018 (1.002 to 1.034) 0.025 |
| Never drinker | 49 681 | 1.010 (1.003 to 1.017) 0.003 |
| Not recorded | 150 497 | 1.007 (1.003 to 1.010)<0.001 |
| Family history of diabetes | 0.109 | |
| No | 206 087 | 1.007 (1.004 to 1.010)<0.001 |
| Yes | 4331 | 1.020 (1.005 to 1.035) 0.010 |
Note 1: Above model adjusted for age, gender, BMI, FPG, TC, TG, HDL-C, LDL-C, ALT, AST, Scr, family history of diabetes, smoking and drinking status.
Note 2: In each case, the model is not adjusted for the stratification variable.
ALT, alanine aminotransferase; AST, aspartate aminotransferase; BMI, body mass index; FPG, fasting plasma glucose; HDL-C, high-density lipoprotein cholesterol; LDL-C, low-density lipid cholesterol; Scr, serum creatinine; TC, total cholesterol; TG, triglyceride.