Table 1.
Composition of natural clinical pulmonary surfactant formulations.
| Surfactant | Source (animal) | Source (material) | % PL | %DPPC | Sup. | % Chol | Proteins |
|---|---|---|---|---|---|---|---|
| Native surfactant | Porcine | Lavage | 80–90 | 36–54 | – | 5 | SP-B+++ SP-C+++ |
| Alveofact (Beractant) | Bovine | Lavage | 88 | 39 | – | 3–4 | SP-B++ SP-C++ |
| BLES | Bovine | Lavage | 95 | 42 | – | 4 | SP-B++ SP-C++ |
| Curosurf (Poractant) | Porcine | Minced tissue | 99 | 35–56 | – | 0.3–1.6 | SP-B++ SP-C++ |
| Infasurf (Calfactant) | Bovine | Lavage | 90–94 | 40 | – | 5 | SP-B++ SP-C++ |
| Surfacen | Porcine | Lavage | 91–95 | 45 | – | 5 | SP-B++ SP-C++ |
| Survanta (Bovactant) | Bovine | Minced tissue | 84 | 75 | DPPC, PA, TGs | NR | SP-B+ SP-C++ |
Abbreviations: Chol: cholesterol; DPPC: dipalmitoyl phosphatidylcholine; PA: palmitic acid; PL: phospholipids; TGs: triglycerides.
Sup: supplemented with; NR: not reported.
Proteins: relative amounts in reference to full proportion in native surfactant (+++ 100%; ++ 40-70%; + 10-30%).
Data taken from Ref. [49] and manufacturers.