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Mechanisms by which the central immunosuppressive cells in the TME function. TAMs, Tregs, and MDSCs create an immunosuppressive TME by recruiting various factors, which in turn produce a robust inhibitory effect on CTL.
CTL indicates cytotoxic T lymphocytes; MDSC, myeloid-derived suppressor cell; TAM, tumor-associated macrophages; TME, tumor microenvironment.
