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. 2022 Sep 6;13:992328. doi: 10.3389/fgene.2022.992328

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Copyright © 2022 Ren and Yu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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(A) CCk-8 results of RPE cells that were under SI (40 mM) or H₂O₂ (200 μM) treatment for 4 h (B) Representative images and the corresponding statistical result of PI staining. The cells were under SI (40 mM) or H₂O₂ (200 μM) treatment for 4 h; scale bar = 200 μm (C) H&E staining of retinal sections from mice at 2 days after 40 mg/kg SI injection; scale bar = 50 μm (D) Quantification of mRNA expression of indicated genes in RPE cells. The cells were under SI (40 mM) or H₂O₂ (200 μM) treatment for 4 h (E) Quantification of mRNA expression of indicated genes in RPE-choroid complex in mouse that were treated with SI for 2 days **p < 0.01, ***p < 0.001, ****p < 0.0001, compared versus control. INL: inner nuclear layer, ONL: outer nuclear layer, RPE: retinal pigmented epithelium.