TABLE 4.
Pathway crosstalk information.
| Pathway A | Pathway B | Score |
| Cells and Molecules involved in local acute inflammatory response | Adhesion and Diapedesis of Granulocytes Focal adhesion | 0.87500 |
| lntegrins in angiogenesis | Focal adhesion | 0.81250 |
| Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix | Ensemble of genes encoding ECM-associated proteins including ECM-affilaited proteins ECM regulators and secreted factors | 0.80556 |
| IL23-mediated signaling events | IL27-mediated signaling events | 0.80000 |
| PI3K-Akt signaling pathway | Focal adhesion | 0.78571 |
| IL-17 signaling pathway | IL27-mediated signaling events | 0.71429 |
| PI3K-Akt signaling pathway | lntegrins in angiogenesis | 0.67857 |
| VEGF Hypoxia and Angiogenesis | HIF-Fluid shear stress and atherosclerosis-alpha transcription factor network | 0.67500 |
| Ensemble of genes encoding core extracellular matrix including ECM glycoproteins collagens and proteoglycans | Genes encoding collagen proteins | 0.66667 |
| IL23-mediated signaling events | ||
| PI3K-Akt signaling pathway | IL-17 signaling pathway | 0.65000 |
| Genes encoding collagen proteins | VEGF Hypoxia and Angiogenesis | 0.64286 |
| Cytokine-cytokine receptor interaction | Protein digestion and absorption | 0.62500 |
| Cytokine-cytokine receptor interaction | IL-17 signaling pathway | 0.61607 |
| Cytokine-cytokine receptor interaction | IL27-mediated signaling events | 0.60000 |
| Free Radical Induced Apoptosis | Glypican 1 network | 0.60000 |
| Cytokines can induce activation of matrix metalloproteinases which degrade extracellular matrix | Adhesion and Diapedesis of Granulocytes | 0.58333 |
| Cytokines can induce activation of matrix metalloproteinases which degrade extracellular matrix | IL27-mediated signaling events | 0.58333 |
| IL27-mediated signaling events | Antifolate resistance | 0.58333 |
| Cytokine-cytokine receptor interaction | ||
| Ensemble of genes encoding core extracellular matrix including ECM glycoproteins collagens and proteoglycans | Antifolate resistance | 0.58333 |
| VEGF Hypoxia and Angiogenesis | IL 5 Signaling Pathway | 0.56667 |
| HIF-Fluid shear stress and atherosclerosis alpha transcription factor network | Protein digestion and absorption | 0.55385 |
| Cells and Molecules involved in local acute inflammatory response | Focal adhesion | 0.54167 |
| VEGF Hypoxia and Angiogenesis | Focal adhesion | 0.54167 |
| HIF-Fluid shear stress and atherosclerosis alpha transcription factor network | Free Radical Induced Apoptosis | 0.53333 |
| ATF-Fluid shear stress and atherosclerosis transcription factor network | Glypican 1 network | 0.53333 |
| Cytokine-cytokine receptor interaction | Glypican 1 network | 0.53333 |
| HIF-1 signaling pathway | Signaling mediated by p38-alpha and p38-beta | 0.53333 |
| IL23-mediated signaling events | IL23-mediated signaling events | 0.52500 |
| IL23-mediated signaling events | VEGF Hypoxia and Angiogenesis | 0.51136 |
| amb2 Integrin signaling | Cytokines can induce activation of matrix metalloproteinases which degrade extracellular matrix | 0.50000 |
| Mechanism of Gene Regulation by Peroxisome Proliferators via PPARa(alpha) | ||
| The IGF-1 Receptor and Longevity | Antifolate resistance | 0.50000 |
| Adhesion and Diapedesis of Granulocytes | 0.50000 | |
| Cytokines can induce activation of matrix metalloproteinases which degrade extracellular matrix | Signaling mediated by p38-alpha and p38-beta | 0.50000 |
| IL27-mediated signaling events | Longevity regulating pathway | 0.50000 |
| Antifolate resistance | Hematopoietic cell lineage | 0.50000 |
| Fluid shear stress and atherosclerosis | ||
| Fluid shear stress and atherosclerosis | Hematopoietic cell lineage | 0.50000 |
| IL-17 signaling pathway | Hematopoietic cell lineage | 0.50000 |
| VEGF Hypoxia and Angiogenesis | 0.48214 | |
| Free Radical Induced Apoptosis | Angiopoietin receptor Tie2-mediated signaling | 0.48214 |
| Adhesion and Diapedesis of Granulocytes | Ensemble of genes encoding ECM-associated proteins including ECM-affilaited proteins ECM regulators and secreted factors | 0.48214 |
| Cytokines can induce activation of matrix metalloproteinases which degrade extracellular matrix | Toll-like receptor signaling pathway | 0.47619 |
| Toll-like receptor signaling pathway | Toll-like receptor signaling pathway | 0.47619 |
| Toll-like receptor signaling pathway | Toll-like receptor signaling pathway | |
| Th17 cell differentiation | 0.47619 | |
| PI3K-Akt signaling pathway | IL27-mediated signaling events | 0.47619 |
| Cytokine-cytokine receptor interaction | Antifolate resistance | 0.47619 |
| Cytokine-cytokine receptor interaction | IL27-mediated signaling events | 0.47619 |
| HIF-1 signaling pathway | HIF-Fluid shear stress and atherosclerosis-alpha transcription factor network | 0.47500 |
| IL-17 signaling pathway | VEGF Hypoxia and Angiogenesis | 0.46875 |
| IL-17 signaling pathway | HIF-Fluid shear stress and atherosclerosis-alpha transcription factor network | 0.46875 |
| IL-17 signaling pathway | PI3K-Akt signaling pathway | 0.46667 |
| IL-17 signaling pathway | Free Radical Induced Apoptosis | 0.45833 |
| Ensemble of genes encoding ECM-associated proteins including ECM-affilaited proteins ECM regulators and secreted factors | Adhesion and Diapedesis of Granulocytes | 0.45833 |
| Focal adhesion | Cytokines can induce activation of matrix metalloproteinases which degrade extracellular matrix | 0.45833 |
| HIF-1 signaling pathway | Antifolate resistance | 0.45833 |
| Angiopoietin receptor Tie2-mediated signaling | 0.45395 | |
| Fluid shear stress and atherosclerosis | ||
| Fluid shear stress and atherosclerosis | Glypican 1 network | 0.44444 |
| Fluid shear stress and atherosclerosis | Glypican 1 network | 0.42424 |
| Fluid shear stress and atherosclerosis | IL-17 signaling pathway | 0.41071 |
| Fluid shear stress and atherosclerosis | Cytokines can induce activation of matrix metalloproteinases which degrade extracellular matrix | 0.40476 |
| Fluid shear stress and atherosclerosis | IL27-mediated signaling events | 0.40476 |
| Fluid shear stress and atherosclerosis | Antifolate resistance | 0.40476 |
| PI3K-Akt signaling pathway | Plasma membrane estrogen receptor signaling | 0.40000 |
| IL23-mediated signaling events | 0.40000 | |
| IL-17 signaling pathway | amb2 Integrin signaling | 0.40000 |
| Cytokine-cytokine receptor interaction | Glypican 1 network | 0.40000 |
| Cytokine-cytokine receptor interaction | Toll-like receptor signaling pathway | 0.40000 |
| Cytokine-cytokine receptor interaction | Free Radical Induced Apoptosis | 0.39583 |
| Plasma membrane estrogen receptor signaling | Adhesion and Diapedesis of Granulocytes | 0.39583 |
| Cells and Molecules involved in local acute inflammatory response | Cytokines can induce activation of matrix metalloproteinases which degrade extracellular matrix | 0.39583 |
| Fat digestion and absorption | Antifolate resistance | 0.39583 |
| lntegrins in angiogenesis | Angiopoietin receptor Tie2-mediated signaling | 0.38596 |
| lntegrins in angiogenesis | amb2 Integrin signaling | 0.38596 |
| amb2 Integrin signaling | ABC transporters | 0.38596 |
| Mechanism of Gene Regulation by Peroxisome Proliferators via PPARa (alpha) | VEGF Hypoxia and Angiogenesis | 0.38596 |
| Free Radical Induced Apoptosis | HIF-Fluid shear stress and atherosclerosis-alpha transcription factor network | 0.38596 |
| Angiopoietin receptor Tie2-mediated signaling | 0.38596 | |
| Adhesion and Diapedesis of Granulocytes | ATF-Fluid shear stress and atherosclerosis transcription factor network | 0.38596 |
| Ensemble of genes encoding ECM-associated proteins including ECM-affilaited proteins ECM regulators and secreted factors | 0.38596 | |
| Ensemble of genes encoding ECM-associated proteins including ECM-affilaited proteins ECM regulators and secreted factors | Ensemble of genes encoding ECM-associated proteins including ECM-affilaited proteins ECM regulators and secreted factors | 0.38596 |
| 0.38596 | ||
| Cells and Molecules involved in local acute inflammatory response | IL27-mediated signaling events | |
| IL23-mediated signaling events | 0.38596 | |
| amb2 Integrin signaling | Toll-like receptor signaling pathway | |
| Ensemble of genes encoding ECM-associated proteins including ECM-affilaited proteins ECM regulators and secreted factors | 0.32500 | |
| Cells and Molecules involved in local acute inflammatory response | Ensemble of genes encoding ECM-associated proteins including ECM-affilaited proteins ECM regulators and secreted factors | 0.37500 |
| 0.31111 | ||
| HIF-1 signaling pathway | IL-17 signaling pathway | 0.37500 |
| HIF-1 signaling pathway | HIF-Fluid shear stress and atherosclerosis-alpha transcription factor network | |
| Cytokine-cytokine receptor interaction | Angiopoietin receptor Tie2-mediated signaling | 0.36111 |
| Cytokine-cytokine receptor interaction | Toll-like receptor signaling pathway | 0.33333 |
| Plasma membrane estrogen receptor signaling | ||
| IL23-mediated signaling events | Th17 cell differentiation | 0.33333 |
| IL23-mediated signaling events | amb2 Integrin signaling | 0.33333 |
| Mechanism of Gene Regulation by Peroxisome Proliferators via PPARa(alpha) | Mechanism of Gene Regulation by Peroxisome Proliferators via PPARa(alpha) | 0.33333 |
| Hematopoietic cell lineage | 0.32500 | |
| Fluid shear stress and atherosclerosis | Hematopoietic cell lineage | 0.32500 |
| PI3K-Akt signaling pathway | HIF-Fluid shear stress and atherosclerosis-alpha transcription factor network | 0.32500 |
| IL23-mediated signaling events | Angiopoietin receptor Tie2-mediated signaling | 0.32500 |
| IL23-mediated signaling events | Toll-like receptor signaling pathway | 0.31667 |
| Toll-like receptor signaling pathway | Th17 cell differentiation | 0.31250 |
| Cytokine-cytokine receptor interaction | Hematopoietic cell lineage | 0.31111 |
| Fluid shear stress and atherosclerosis | Cells and Molecules involved in local acute inflammatory response | 0.31111 |
| Cells and Molecules involved in local acute inflammatory response | Cytokine-cytokine receptor interaction | 0.31111 |
| Ensemble of genes encoding ECM-associated proteins including ECM-affilaited proteins ECM regulators and secreted factors | 0.30882 | |
| 0.27143 | ||
| IL-17 signaling pathway | amb2 Integrin signaling | 0.30000 |
| IL-17 signaling pathway | Hematopoietic cell lineage | |
| Ensemble of genes encoding ECM-associated proteins including ECM-affilaited proteins ECM regulators and secreted factors | ATF-Fluid shear stress and atherosclerosis transcription factor network | 0.30000 |
| Fluid shear stress and atherosclerosis | 0.30000 | |
| Ensemble of genes encoding ECM-associated proteins including ECM-affilaited proteins ECM regulators and secreted factors | 0.30000 | |
| Fluid shear stress and atherosclerosis | ||
| Phagosome | Focal adhesion | 0.25758 |
| Fat digestion and absorption | 0.28846 | |
| Phagosome | Hematopoietic cell lineage | |
| HIF-1 signaling pathway | Plasma membrane estrogen receptor signaling | 0.28750 |
| HIF-1 signaling pathway | lntegrins in angiogenesis | 0.28333 |
| HIF-1 signaling pathway | ||
| Ensemble of genes encoding core extracellular matrix including ECM glycoproteins collagens and proteoglycans | Mineral absorption | 0.28333 |
| Focal adhesion | 0.27692 | |
| Plasma membrane estrogen receptor signaling | ||
| 0.27692 | ||
| Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix | 0.27692 |
| amb2 Integrin signaling | 0.27574 | |
| Ensemble of genes encoding core extracellular matrix including ECM glycoproteins collagens and proteoglycans | ||
| Fluid shear stress and atherosclerosis | lntegrins in angiogenesis | 0.27143 |
| 0.27143 | ||
| Fluid shear stress and atherosclerosis | lntegrins in angiogenesis | |
| Cytokine-cytokine receptor interaction | Mineral absorption | 0.26667 |
| Plasma membrane estrogen receptor signaling | Hematopoietic cell lineage | |
| IL-17 signaling pathway | Focal adhesion | 0.26250 |
| Cytokine-cytokine receptor interaction | PI3K-Akt signaling pathway | 0.26250 |
| Th17 cell differentiation | 0.26250 | |
| Cytokine-cytokine receptor interaction | Ensemble of genes encoding ECM-associated proteins including ECM-affilaited proteins ECM regulators and secreted factors | 0.26250 |
| Cytokine-cytokine receptor interaction | 0.25882 | |
| lntegrins in angiogenesis | 0.12795 | |
| 0.25758 | ||
| Plasma membrane estrogen receptor signaling | Hematopoietic cell lineage | .25595 |
| Phagosome | Ensemble of genes encoding ECM-associated proteins including ECM-affilaited proteins ECM regulators and secreted factors | |
| Fluid shear stress and atherosclerosis | Toll-like receptor signaling pathway | 0.25556 |
| Fluid shear stress and atherosclerosis | Toll-like receptor signaling pathway | 0.25556 |
| Cytokine-cytokine receptor interaction | HIF-1 signaling pathway | 0.24762 |
| PI3K-Akt signaling pathway | PI3K-Akt signaling pathway | |
| Toll-like receptor signaling pathway | Toll-like receptor signaling pathway | 0.24359 |
| Ensemble of genes encoding ECM-associated proteins including ECM-affilaited proteins ECM regulators and secreted factors | 0.22549 | |
| PI3K-Akt signaling pathway | 0.22500 | |
| Fluid shear stress and atherosclerosis | Ensemble of genes encoding core extracellular matrix including ECM glycoproteins collagens and proteoglycans | 0.22286 |
| Fluid shear stress and atherosclerosis | PI3K-Akt signaling pathway | 0.22222 |
| HIF-1 signaling pathway | Focal adhesion | 0.21212 |
| Ensemble of genes encoding ECM-associated proteins including ECM-affilaited proteins ECM regulators and secreted factors | Phagosome | 0.58333 |
| PI3K-Akt signaling pathway | Focal adhesion | 0.19022 |
| 0.17788 | ||
| PI3K-Akt signaling pathway | Ensemble of genes encoding ECM-associated proteins including ECM-affilaited proteins ECM regulators and secreted factors | 0.17763 |
| 0.16993 | ||
| HIF-1 signaling pathway | Phagosome | 0.16667 |
| Complement and coagulation cascades | Cytokine-cytokine receptor interaction | |
| HIF-1 signaling pathway | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix | 0.15887 |
| HIF-1 signaling pathway | Ensemble of genes encoding ECM-associated proteins including ECM-affilaited proteins ECM regulators and secreted factors | 0.15873 |
| Fluid shear stress and atherosclerosis | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix | |
| Ensemble of genes encoding ECM-associated proteins including ECM-affilaited proteins ECM regulators and secreted factors | 0.14348 | |
| Complement and coagulation cascades | 0.51136 | |
| 0.14091 | ||
| 0.13846 | ||
| 0.13636 | ||
| 0.12795 |