Table 2.

Schedule of assessments

	Assessment	Screen	Baseline scan	Week 1	Week 2	Week 3	Post-Tx scan (Week 4)	Week 6
Eligibility and safety assessments	Consent form	x
	Characterisation of pain	x
	Physical examination	x
	Medical history	x
	Concomitant medications	x	x
	Adverse events		x	x	x	x	x	x
	C-SSRS (suicidality)	x	x		x		x	x
	Urine drug test (10-Panel)	x	x				x
	Urine pregnancy test	x
	Serum pregnancy test		x				x
	Liver function tests	x					x
Primary outcome	[11C]PBR28 Signal in Thalamus		x				x
Secondary outcomes	[11C]PBR28 Signal in Limbic Regions (pgACC, aMCC)		x				x
	‘Worst Pain’ item of BPI-SF (0–10 scale)	Daily survey ratings from~2 weeks before scan I until Week 6
	Pain Bothersomeness Ratings (0–10 scale)	Daily survey ratings from~2 weeks before scan I until Week 6
	BDI-II	x	x				x	x
	PGIC						x
Exploratory outcomes	Reward Task (MID)		x				x
	BPI-SF	x	x				x	x
	PCS		x		x		x	x
	PainDETECT		x				x
	ODI		x				x
	ACR Fibromyalgia Survey		x		x		x
	Depression Ratings (0–10 scale)	Daily survey ratings from~2 weeks before scan I until week 6
	PROMIS-29		x				x
	PSQI	x	x				x
	SymptomMapper		x				x

BDI-II, Beck Depression Inventory; BPI-SF, Brief Pain Inventory-Short Form; MID, Monetary Incentive Delay Task; ODI, Oswestry Disability Index; PCS, Pain Catastrophizing Scale; PGIC, Patient Global Impression of Change; PROMIS-29, Patient Reported Outcomes Measurement Information System–29; PSQI, Pittsburgh Sleep Quality Index.