Table 2. Adverse Effects and Their Severity.
| Adverse effect | No. (%) (N = 175) |
|---|---|
| Any adverse effect | 85 (48.6) |
| Nausea and vomiting | 64 (36.6) |
| Diarrhea | 15 (8.6) |
| Fatigue | 11 (6.3) |
| Constipation | 10 (5.7) |
| Abdominal pain | 9 (5.1) |
| Headache | 5 (2.9) |
| Acid reflux | 4 (2.3) |
| Othersa | 8 (4.8) |
| Adverse effect severity | |
| None | 90 (51.4) |
| Mildb | 65 (37.1) |
| Moderateb | 15 (8.6) |
| Severeb | 5 (2.9) |
a
Other adverse effects included dizziness, depression, bloating, dry mouth, and taste change.
b
Mild adverse effects did not affect dose escalation; moderate adverse effects prevented dose escalation; and severe adverse effects resulted in medication termination.