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. 2022 Sep 20;576:61–68. doi: 10.1016/j.virol.2022.09.003

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Fig. 1 — Physical and Chemical Characterization of SCTV01C. (a) Schematic diagram of SCTV01C antigens. (b) SDS-PAGE analysis of SCTV01C antigens. (c) Binding affinity of SCTV01C antigens to human ACE2. (d,e) Thermal stability of SCTV01C antigens analyzed by Differential Scanning Fluorimetry (DSF). (f) Real-time stability of SCTV01C antigens at 25 ^oC evaluated by SEC-HPLC. (g) Balb/c mice (n = 10) were vaccinated with a single dose of SCTV01C (2 μg/dose for left panel; five dose levels for right panel: 0.5, 1, 2, 4 and 8 μg/dose). Sera were collected 4 weeks later for detection of relative antigen-specific IgG titer and relative pseudovirus neutralizing activities. Dashed line represents the value of criterion.