TABLE 2.
Inhibition effects of BoA derivatives on the growth of tumor cells and MDCK cells in vitro.
| Half maximal inhibitory concentration (IC50) values (µM) | |||||
|---|---|---|---|---|---|
| Compound | HepG2 | Bel-7402 | Hela | MCF-7 | MDCK |
| BoAA | 13.47 ± 1.80 | 8.16 ± 2.08 | 18.27 ± 1.63 | 15.66 ± 0.55 | >30 |
| BoAB | 11.08 ± 0.27 | 7.73 ± 1.92 | 11.80 ± 0.58 | 10.02 ± 0.26 | >30 |
| BoAC | 8.95 ± 4.76 | 8.24 ± 2.43 | 11.91 ± 1.05 | 8.94 ± 1.30 | >30 |
| BoAD | 5.17 ± 1.33 | 7.51 ± 1.40 | 10.69 ± 0.32 | 8.24 ± 0.87 | >30 |
| BoAE | - a | - | - | - | - |
| BoA2A | 13.73 ± 0.25 | 8.76 ± 0.84 | 24.97 ± 0.97 | 9.86 ± 0.36 | >30 |
| BoA2B | 13.44 ± 1.82 | 10.06 ± 1.40 | 15.48 ± 0.81 | >30 | >30 |
| BoA2C | 7.46 ± 1.43 | 3.65 ± 0.43 | 15.59 ± 2.63 | 3.39 ± 0.07 | >30 |
| BoA2D | 7.32 ± 2.88 | 8.22 ± 0.43 | 14.93 ± 1.84 | 8.32 ± 1.28 | >30 |
| BoA2E | - | - | - | - | - |
| BoA2F | >30 | >30 | 15.20 ± 1.07 | 29.65 ± 0.37 | 12.50 ± 1.22 |
| BoA2G | >30 | 24.81 ± 2.43 | 5.81 ± 0.24 | >30 | 12.97 ± 0.46 |
| BoA3A | 4.82 ± 0.30 | 6.09 ± 0.12 | 20.41 ± 0.56 | 6.85 ± 1.82 | >30 |
| BoA3B | 13.16 ± 1.20 | 14.24 ± 2.10 | 15.71 ± 2.15 | 27.88 ± 1.06 | >30 |
| BoA3C | >30 | 9.37 ± 1.31 | 29.98 ± 2.65 | 10.02 ± 0.19 | >30 |
| BoA3D | 8.65 ± 0.60 | 6.42 ± 0.66 | 9.50 ± 0.28 | 5.60 ± 0.25 | 17.01 ± 3.01 |
| BoA3E | 20.18 ± 0.53 | 11.21 ± 1.55 | 10.13 ± 0.15 | 29.48 ± 0.89 | >30 |
| BoA3F | >30 | 22.31 ± 5.85 | 21.09 ± 6.66 | >30 | 17.93 ± 0.82 |
| BoA3G | >30 | 25.25 ± 2.44 | 4.00 ± 0.32 | 13.44 ± 0.51 | 18.53 ± 0.42 |
| BoA4A | 12.89 ± 4.00 | 9.39 ± 0.73 | 13.82 ± 0.12 | 9.13 ± 0.40 | 25.32 ± 4.14 |
| BoA4B | 21.83 ± 2.46 | 3.92 ± 1.10 | 11.47 ± 0.93 | >30 | >30 |
| BoA4C | 22.18 ± 1.76 | 5.53 ± 0.46 | 17.87 ± 0.45 | 9.88 ± 1.49 | >30 |
| BoA4D | >30 | 16.29 ± 0.90 | 15.74 ± 2.15 | >30 | >30 |
| BoA4E | >30 | >30 | >30 | >30 | >30 |
| BoA4F | 30.23 ± 1.51 | >30 | 25.86 ± 0.57 | 24.47 ± 5.17 | 27.22 ± 0.25 |
| BoA4G | 29.27 ± 0.22 | 19.43 ± 1.20 | 7.46 ± 1.99 | 12.77 ± 0.15 | 16.93 ± 1.03 |
| BoA | >30 | >30 | 27.04 ± 1.06 | >30 | >30 |
| DDP b | 5.23 ± 1.03 | 8.86 ± 1.32 | 9.84 ± 2.54 | 6.98 ± 0.32 | 13.69 ± 1.45 |
a
“-” was meant that the IC50 values of the compounds can’t be determined accurately because of their poor solubility in DMSO.
b
DDP (cisplatin) was used as positive control.