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. 2022 Sep 5;13:898799. doi: 10.3389/fimmu.2022.898799

Figure 4.

Figure 4

NAC treatment significantly reduced hepatic steatosis in HFD mice. (A) The fluorescence intensity image, the LLS mapped image, the calculated size distribution maps, and the corresponding phasor plot. The red cursor was used to select the LLS lifetime signature originating from the intensity image and the LLS image was colored according to that phasor signature. The size map was created to show the distribution of the droplets. (B, C) The size map was created to show the distribution of the droplets. (B, C) The size distribution plots for Control (B) and NAC (C) treatment. The Y axis is shown in logscale to exemplify the increasing size as a function of diet and IRI. The distribution shows HFD and IRI induce the large lipid droplets and (especially above 10000 pixels) are lower in number in HFD + NAC, groups. (n=5-7 mice per group). (D) The average size distribution of lipid droplets from the livers of the animals in different feeding regimen. “*” 0.05 to 0.01, “**”0.01 to 0.001.