Table 3.
Logistic regression models for acute erythema (0/1).
| Non-SNP model | + rs2087947 C/T (PER3) (fixed effects) |
+ rs2087947 C/T (PER3) (random effects) |
|
|---|---|---|---|
| BMI |
1.04 (1.02 – 1.07) P = 0.0005 |
1.04 (1.02 – 1.07) P = 0.0006 |
1.05 (1.03 – 1.08) P < 0.0001 |
| Biological equivalent dose to breast (BED) (Gy) |
1.02 (1.01 – 1.03) P = 0.0004 |
1.02 (1.01 – 1.03) P = 0.0005 |
1.02 (1.01 – 1.04) P = 0.003 |
| Mean treatment time (hours from solar midnight) |
1.05 (0.999 – 1.1) P = 0.05 |
1.05 (1 – 1.1) P = 0.043 |
1.02 (0.966 – 1.07) P = 0.49 |
| Standard deviation of treatment times (solar time) |
0.64 (0.491 – 0.832) P = 0.0009 |
0.645 (0.495 – 0.839) P = 0.001 |
0.812 (0.545 – 1.08) P = 0.2 |
| rs2087947 (dosage, T allele) |
1.27 (1.03 – 1.56) P = 0.024 |
1.27 (1 – 1.54) P = 0.027 |
|
| (Random Effect) Treatment centre stdev:__(Intercept) |
0.59 | ||
| N | 1198 | 1198 | 1198 |
| ROC AUC (95% CI) a | 0.61 (0.55–0.67) | 0.62 (0.56–0.68) | |
| AIC | 1,244 | 1,241 | 1,203 |
Logistic regression. Statistics shown: odds ratio (95% CI).
see Supplementary Figure 1.