Table 2.
All white matter tracts showing increased FA levels in MDMA users.
| White matter tract | Significant segments1 | FWE-corrected p-value2 |
|---|---|---|
| Corpus callosum [Genu] | 63 [midline] | 0.032 |
| Corpus callosum [anterior midbody] | 43–44 [right of midline] | 0.001 |
| Corpus callosum [posterior midbody] | 13–14, 84 [left and right distal] | 0.030 |
| Corpus callosum [Isthmus] | 92–97 [right distal] | <0.0001 |
| Corticospinal tract [left] | 28 [distal superior] | 0.029 |
| Corticospinal tract [right] | 51 [middle] | 0.032 |
| Inf. occipito-frontal fascicle [left] | 23–25 [distal frontal] | 0.003 |
| Sup. longitudinal fascicle I [left] | 50 [middle] | 0.041 |
| Uncinate fascicle [right] | 62–63 [middle] | 0.038 |
| Thalamo-parietal tract [right] | 54 [middle] | 0.049 |
| Striato-fronto-orbital tract [left] | 45 [middle] | 0.044 |
1
Numbers reflect segment numbers within tracts, which were all segmented into 100 segments. Thus, number reflects left to right, superior to inferior, or frontal to posterior position along tract depending on their orientation in the brain. In brackets, the relative location of the significant area within the tract is indicated.
2
In case of multiple significant segments, the minimal p-value is shown.