Table 3.

Univariate and multivariable analysis of recurrence-free survival

	Univariate Analysis for RFS		Multivariable Analysis for RFS
Characteristic	HR (95% CI for HR)	p- value	HR (95% CI for HR)	p- value
Age ≥50 (X-tile)	1.33 (0.79-2.26)	0.284
Age ≥60 (median)	0.91 (0.64-1.31)	0.617
Age ≥62 (mean)	0.95 (0.64-1.36)	0.78
Hgb
Below normal	1	.
Normal	0.67 (0.44-1.02)	0.065
Corrected Ca++
Normal	1	.
Above normal	1.25 (0.72-2.17)	0.423
LDH
Normal	1	.
Above normal	1.27 (0.8-2.02)	0.318
EGFR
<45	1	.
≥45	0.76 (0.35-1.62)	0.473
Sex
Male	1	.
Female	0.92 (0.64-1.34)	0.678
Race
White	1	.
Hispanic	0.91 (0.59-1.42)	0.686
Black	1 (0.43-2.33)	0.997
T stage
3b	1	.
3c	1.42 (0.87-2.3)	0.157
Clinical N1	2.67 (1.54-4.63)	<0.001	2.63 (1.51-4.6)	0.01
Pre-surgery embolize	0.75 (0.46-1.2)	0.226
Side
Left	1	.
Right	1.06 (0.71-1.6)	0.768
Hypertension	0.78 (0.54-1.12)	0.172
Diabetes mellitus	0.77 (0.49-1.22)	0.267
Coronary artery disease	1.27 (0.76-2.13)	0.362
Peripheral vascular disease	2.67 (0.65-11)	0.175
Microhematuria	1.14 (0.46-2.83)	0.776
Gross hematuria	0.83 (0.56-1.21)	0.328
Flank pain	0.92 (0.63-1.35)	0.67
Weight loss >10 lbs	2.02 (1.36-2.99)	<0.001	1.76 (1.18-2.65)	0.006
Malaise, weakness, fatigue	1.22 (0.83-1.8)	0.3
New-onset congestive heart failure	1.75	0.134
Non-clear cell histologic type	2.29 (1.3-4.04)	0.004	2.08 (1.17-3.69)	0.01
Grade
0-2	1	.
3	0.8 (0.44-1.46)	0.468
4	1.42 (0.77-2.64)	0.263
Sarcomatoid	2.43 (1.38-4.27)	0.002	1.76 (0.98-3.15)	0.054
Rhabdoid	1.43 (0.45-4.53)	0.547