Table 3.

Outcome assessment and treatment received in the included studies.

No	Author & years of publication	Surgical Intervention	NLR (mean ± SD)	NLR Cut-off	Cut-off point calculation	Median OS	Median CSS	Primary Outcome	Secondary Outcome
1	Kasuga et al., 2016	Radical Penectomy	5.03 ± 4.99	2.82	AUC	NR	NR	OS, CSS	LNM
2	Tan et al., 2017	Bilateral modified inguinal lymph node dissection or dynamic sentinel node biopsy	2.99 (0.76–5.22)∗∗	2.8	AUC	NR	NR	CSS, PFS,	LNM
3	Azizi et al., 2018	Bilateral/unilateral inguinal lymph node dissection	4.51 ± 3.95	3	Contal and O'Quigley method	89 (31.2–123.6) months∗∗	NR	OS, CSS, RFS	LNM
4	Li et al., 2019	Bilateral inguinal lymph node dissection	2.4 (0.1–44.2)∗	2.6	ROC	NR	NR	CSS	LNM
5	Jiao Hu et al., 2020	Bilateral inguinal lymph node dissection after primary tumor procedure	NR	3.59	ROC	NR	NR	CSS	LNM
6	Chen Hu et al., 2020	Inguinal lymph node dissection	NR	2.94	AUC	34 (18–84) months∗∗	33 (18–85.25) months∗∗	OS, PFS	LNM
7	Jindal et al., 2021	Penectomy with bilateral inguinal node dissection	NR	3	Following previous study by Azizi et al.	NR	18 (2–74) months∗	CSS	LNM

NLR = Neutrophil-lymphocyte ratio, ROC = Receiver operating characteristic curve, AUC = Area under the curve, OS = Overall Survival, CSS = Cancer specific-survival, PFS = Progression-free survival, LNM = Lymph-Node Metastasis.

^∗Data expressed as median and range.

^∗∗Data expressed as median and interquartile (IQR) range.