Table 5.

Revised Cochrane risk-of-bias tool for randomized trials (RoB 2) [51].

Study	Risk of Bias Domains
	D1	D2	D3	D4	D5	Overall
Xie L et al [5] 2021
	-	+	X	+	+	X
Larsen MK et al [18] 2021
	+	-	-	+	+	-
Lindeboom JA et al [19] 2021
	-	-	+	+	+	+
Erdil A et al [20] 2020
	+	+	-	+	-	-
Ai Lyn Lau A et al [22] 2020
	+	+	-	+	+	+
Fennis JP et al [27] 2017
	+	-	-	-	+	-
Ibikunle AA et al [32] 2016
	+	+	-	+	+	+
Rodanant P et al [33] 2016
	-	+	+	+	+	+
Sierra SO et al [38] 2013
	+	+	+	-	+	+
Deepti C et al [1] 2009
	-	X	-	-	+	X

Domains: Judgement:
D1: Bias arising from the randomization process
X
D2: Bias due to deviations from intended intervention High
-
D3: Bias due to missing outcome data Some concerns
+
D4: Bias in measurement of the outcome Low
D5: Bias in selection of the reported result