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. 2022 Aug 19;81:104463. doi: 10.1016/j.amsu.2022.104463

Table 1.

Showing pre-operative desensitization protocol.

Protocol Day Desensitization Therapy Anti-A & Anti-B titer level and CD-19 count
Pre-LT:day-23 Inj. Rituximab 375 mg/m2 = 700mg I.V slow
Inj. Bortezomib 1.3 mg/m2 = 2mg I.V slow
Pre-LT:day-20 Inj. Bortezomib 1.3 mg/m2 = 2mg Subcutaneous(S/C)
Pre-LT:day −16 Inj. Bortezomib 1.3 mg/m2 = 2mg S/C
Pre-LT:day −13 Inj. Bortezomib 1.3 mg/m2 = 2mg S/C
Pre-LT:day-7 Tab. Mycophenolate mofetil 500 mg twice daily
Tab. Tacrolimus 1 mg twice daily
Pre-LT:day-5 Therapeutic plasmapheresis Anti-A & Anti-B titer level = 1:32
Pre-LT:day-3 Therapeutic plasmapheresis Anti-A & Anti-B titer level = 1:16
Pre-LT: day-1 Therapeutic plasmapheresis Anti-A & Anti-B titer level = 1:4
CD 19 activity = 1.6%
Operative day (day-0) LT procedure performed
Inj. Basiliximab 0.8 gm/kg I.V (During anhepatic phase)
Post-LT:day-15 Anti-A & Anti-B titer level = 1:16
CD 19 activity = < 3%
Post-LT:3 months Anti-A & Anti-B titer level = 1:16