Table 1.
Showing pre-operative desensitization protocol.
| Protocol Day | Desensitization Therapy | Anti-A & Anti-B titer level and CD-19 count |
|---|---|---|
| Pre-LT:day-23 | Inj. Rituximab 375 mg/m2 = 700mg I.V slow | |
| Inj. Bortezomib 1.3 mg/m2 = 2mg I.V slow | ||
| Pre-LT:day-20 | Inj. Bortezomib 1.3 mg/m2 = 2mg Subcutaneous(S/C) | |
| Pre-LT:day −16 | Inj. Bortezomib 1.3 mg/m2 = 2mg S/C | |
| Pre-LT:day −13 | Inj. Bortezomib 1.3 mg/m2 = 2mg S/C | |
| Pre-LT:day-7 | Tab. Mycophenolate mofetil 500 mg twice daily | |
| Tab. Tacrolimus 1 mg twice daily | ||
| Pre-LT:day-5 | Therapeutic plasmapheresis | Anti-A & Anti-B titer level = 1:32 |
| Pre-LT:day-3 | Therapeutic plasmapheresis | Anti-A & Anti-B titer level = 1:16 |
| Pre-LT: day-1 | Therapeutic plasmapheresis | Anti-A & Anti-B titer level = 1:4 |
| CD 19 activity = 1.6% | ||
| Operative day (day-0) | LT procedure performed | |
| Inj. Basiliximab 0.8 gm/kg I.V (During anhepatic phase) | ||
| Post-LT:day-15 | Anti-A & Anti-B titer level = 1:16 | |
| CD 19 activity = < 3% | ||
| Post-LT:3 months | Anti-A & Anti-B titer level = 1:16 |