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. 2022 Aug 4;17(9):2425–2436. doi: 10.1021/acschembio.2c00040

Figure 2.

Figure 2

Peptides inhibit infection with H1N1 and H5N1 viruses. MDCKI cells were infected with H1N1pdm09 (A/Netherlands/602/2009) (a), H1N1pr8 (A/PR8/8/34/Mount Sinai) (b), H5N1 virus carrying H5 HA of A/duck/Hunan/795/2002 in the H1N1pr8 genetic background (c), and H3N1 virus carrying H3 HA of A/Bilthoven/1761/76 (H3N2) in the H1N1pr8 background (d) in the presence of macrocyclic peptides L2, L4, S3, and S5 at 5 μM. Left: representative images of immunofluorescence staining of the IAV nucleoprotein (green). Nuclei are labeled with DAPI (blue). Right: quantification of infected cells relative to untreated control. Data are shown as mean ± SD (n = 3).