Table 3.
Cholesterol profile of patients aged ≥ 66 years with familial hypercholesterolemia (FH) and severe hypercholesterolemia at diagnosis and follow-up
| Characteristic | Definite FH |
Probable FH |
Severe hypercholesterolemia |
General population |
|---|---|---|---|---|
| n = 968 | n = 1,472 | n = 72,893 | n = 847,313 | |
| Cholesterol at index diagnosis, mmol/L∗ | ||||
| Total cholesterol | 9.35 ± 1.34 | 6.68 ± 0.94 | 6.84 ± 0.99 | 4.94 ± 1.08 |
| LDL-C | 7.03 ± 1.29 | 4.53 ± 0.81 | 4.71 ± 0.82 | 2.92 ± 0.89 |
| LDL-C (adjusted)† | 9.52 ± 1.19 | 5.83 ± 0.76 | 5.73 ± 0.70 | 3.33 ± 0.80 |
| HDL-C | 1.48 ± 0.39 | 1.39 ± 0.35 | 1.46 ± 0.36 | 1.40 ± 0.41 |
| Triglyceride | 2.09 ± 0.84 | 1.93 ± 0.82 | 1.75 ± 0.72 | 1.44 ± 0.68 |
| Cholesterol at 2+ years follow-up, mmol/L | ||||
| Number of individuals with follow-up | n = 953 | n = 1435 | n = 72,166 | n = 830,278 |
| Time of follow-up, d | 883 (784–1088) | 893 (790–1106) | 911 (791–1142) | 919 (784–1180) |
| Total cholesterol | 6.16 ± 1.79 | 5.11 ± 1.34 | 5.34 ± 1.28 | 4.43 ± 1.07 |
| LDL-C | 3.88 ± 1.64 | 2.94 ± 1.12 | 3.16 ± 1.11 | 2.39 ± 0.87 |
| HDL-C | 1.47 ± 0.36 | 1.38 ± 0.37 | 1.45 ± 0.37 | 1.40 ± 0.42 |
| Triglyceride | 1.75 ± 0.98 | 1.72 ± 0.94 | 1.58 ± 0.76 | 1.41 ± 0.75 |
| Control of LDL cholesterol at 2+ years follow-up | ||||
| LDL-C < 2.0 mmol/L | 71 (7.5) | 285 (19.9) | 9,764 (13.5) | 286,346 (34.5) |
| ≥ 50% reduction in LDL-C | 657 (68.9) | 730 (50.9) | 29,707 (41.2) | |
| Cholesterol values at 5+ years follow-up, mmol/L | ||||
| Number of individuals with follow-up | n = 896 | n = 1324 | n = 68,760 | n = 762,977 |
| Time of follow-up, in d | 2017 (1902–2227) | 2020 (1899–2221) | 2030 (1910–2246) | 2046 (1915–2284) |
| Total cholesterol | 5.85 ± 1.78 | 4.88 ± 1.32 | 5.11 ± 1.30 | 4.33 ± 1.09 |
| LDL-C | 3.58 (1.60) | 2.72 (1.11) | 2.93 (1.12) | 2.27 (0.89) |
| HDL-C | 1.48 ± 0.39 | 1.39 ± 0.38 | 1.46 ± 0.39 | 1.41 ± 0.43 |
| Triglyceride | 1.72 ± 1.02 | 1.71 ± 0.90 | 1.58 ± 0.78 | 1.44 ± 0.79 |
| Control of LDL cholesterol at 5+ years follow-up | ||||
| LDL-C < 2.0 mmol/L | 94 (10.5) | 355 (26.8) | 13,418 (19.5) | 291,369 (38.2) |
| ≥ 50% reduction in LDL-C | 638 (71.2) | 767 (57.9) | 32,641 (47.5) | |
Values are mean ± standard deviation, median (interquartile range), or n (%).
FH, familial hypercholesterolemia; HDL-C, high-density lipoprotein cholesterol; LDL-C, low-density lipoprotein cholesterol.
∗
SI conversion factors: to convert LDL-, HDL-, and total cholesterol and triglyceride levels to milligrams per decilitre, divide by 0.0259.
†
Adjusted LDL-C was estimated by multiplying LDL-C levels for individuals with a known statin prescription in the 100 days prior to their LDL-C test by 1.43 to estimate untreated LDL-C levels.