Fig. 9.

TIME and its prognostic value differ between female and male patients. A Density (cells/mm²) and count within analyses of immune cell populations infiltrating the stromal and the intra-tumoral regions of lymph node metastases in female and male patients. Significantly different data are represented by *p < 0.05, **p < 0.01 and ***p < 0.001. B-C Kaplan-Meier survival curves of disease-free survival for female and male patients according to the immune cell composition and cell-to-cell interactions in (B) primary OPSCC and (C) lymph node metastases. The median cut-off of each immune cell subset density and percentage was used to separate high and low infiltrated groups. Log-rank p values are reported for each sex in each graph