Table 2.
Clinical and demographic characteristics of subjects according to HPV status
| All patients | HPV-negative | HPV-positive | |||||
|---|---|---|---|---|---|---|---|
| n | (%) | n | (%) | n | (%) | p-value | |
| Age (years) | |||||||
| Median (range) | 61 (51–85) | 59 (52–85) | 62 (51–85) | .599 | |||
| Sex | |||||||
| Woman | 16 | (41.0) | 4 | (26.7) | 12 | (50.0) | .150 |
| Man | 23 | (59.0) | 11 | (73.3) | 12 | (50.0) | |
| Tobacco smoking | |||||||
| Never | 11 | (28.2) | 0 | (0.0) | 11 | (45.8) | .020 |
| Ever | 28 | (71.8) | 15 | (100.0) | 13 | (54.02) | |
| Alcohol drinking | |||||||
| Never | 21 | (53.8) | 6 | (40.0) | 15 | (62.5) | .141 |
| Ever | 18 | (46.2) | 9 | (60.0) | 9 | (37.5) | |
| Sub-site | |||||||
| Base of tongue | 7 | (17.9) | 3 | (20.0) | 4 | (16.7) | .792 |
| Tonsil | 32 | (82.1) | 12 | (80.0) | 20 | (83.3) | |
| pTa | |||||||
| T1 | 10 | (25.6) | 2 | (13.3) | 8 | (33.3) | .146 |
| T2 | 14 | (35.9) | 4 | (26.7) | 10 | (41.7) | |
| T3 | 9 | (23.1) | 6 | (40.0) | 3 | (12.5) | |
| T4 | 6 | (15.4) | 3 | (20.0) | 3 | (12.5) | |
| pNa | |||||||
| N1 | 21 | (53.8) | 3 | (20.0) | 18 | (75.0) | .001 |
| N2 | 14 | (35.9) | 8 | (53.3) | 6 | (25.0) | |
| N3 | 4 | (10.3) | 4 | (26.7) | 0 | (0.0) | |
| pStagea | |||||||
| I | 13 | (33.3) | 0 | (0.0) | 13 | (33.3) | <.000 |
| II | 10 | (25.6) | 0 | (0.0) | 10 | (25.6) | |
| III | 3 | (7.7) | 2 | (13.3) | 1 | (4.2) | |
| IV | 13 | (33.3) | 13 | (86.7) | 0 | (0.0) | |
| Grading | |||||||
| G2 | 16 | (41.0) | 9 | (60.0) | 7 | (29.2) | .058 |
| G3 | 23 | (59.0) | 6 | (40.0) | 17 | (70.8) | |
| Adjuvant treatment | |||||||
| None | 12 | (30.8) | 2 | (13.3) | 10 | (41.7) | .083 |
| (Chemo)-radiotherapy | 27 | (69.2) | 13 | (86.7) | 14 | (58.3) | |
a According to TNM classification 8th edition, 2017