Table 1.
Main characteristics of studies including data on HPV vaccination.
| First author and year | Country | Data source (and target population) | Sample size | Outcome measure | Main findings | aNOS score (max 7) | |
|---|---|---|---|---|---|---|---|
| 1 | (Casey et al., 2022) | United States | Population-level healthcare administrative data (adolescents aged 10–18 years) | NR | Number of vaccine doses administered monthly | From March to May 2020, monthly HPV vaccine declined up to 15 doses (vs. 376/month in the period March 2016–December 2019), rebounding to 25 monthly doses in October 2020. | 7 |
| 2 | (Daniels et al., 2021) | United States | Individual-level healthcare claims data from insurers' database (population aged 9–26 years) | NR | Vaccination coverage | Coverage decreased through March and April 2020, reaching a low of 23% of the rate for the previous years (2018–2019). Coverage increased through May and June 2020 to a high of 79% of the previous rate and fell again in July and August. | 6 |
| 3 | (Gabutti et al., 2021) | Italy | Population-level healthcare administrative data (15-year-old girls) | NA | Vaccination coverage | Full-cycle coverage for 15-year-old girls has been equal 63.8%, with a decrease compared to the previous year (70.4%). | 6 |
| 4 | (Ramírez et al., 2022) | Spain | Doses of HPV vaccines distributed by pharmacies during 2008–2020 | NA | Temporal trend in vaccination coverage in women aged 15–55 years not included in vaccination programs during 2007–2020 | In 2020, it was estimated that 4.0% in women aged 15–55 years not included in vaccination programs were vaccinated against HPV, representing an absolute increase of 0.4% from 2019. | 6 |
| 5 | (Sabbatucci et al., 2022) | Italy | Population-level healthcare administrative data (13-year-old girls) | NR | Vaccination full-cycle coverage | Vaccination coverage decreased from 60.8% in 2019 (168,680/277,302) to 58.7% in 2020 (160,219/273,154), for a difference of −2.2 | 6 |
| 6 | (Saxena et al., 2021) | United States | Individual-level healthcare claims data from insurers' database (population aged 9–16 years) | NR | Total vaccine doses administered | HPV vaccine doses administered in 2019 were 446,431, with an average monthly number of doses 37,203. In 2020, these numbers were respectively 339,408 and 28,284, with a total reduction of 24% between the two years. | 6 |
Abbreviations: HPV, human papillomavirus; aNOS, adapted version of the Newcastle-Ottawa Scale checklist for assessing the quality of non-randomized studies; NR, not reported; NA, not applicable; 95% CI, 95% confidence interval.