FIGURE 1.

a) Biopsy of the left parietal pleura in a case of generalised lymphatic anomaly showing complex proliferation of vascular spaces infiltrating fibroadipose tissue. Haematoxylin and eosin staining. b) In different areas, the walls of the lymphatic channels are formed by smooth muscle cells expressing desmin but not oestrogen and progesterone receptors. No reaction with the monoclonal antibody HMB-45 was found. c, d) The lymphatic endothelium is characterised by a diffuse and strong expression of D2-40, shown here at two different scales. Images courtesy of Barberis Massimo (Istituto Europeo di Oncologia, Milan, Italy).