Table 2. Long-term survival outcomes in medically treated chronic post-embolic pulmonary hypertension patients.
Treatment | Administration | First author [Ref.] | Patients n | NYHA-FC | 6MWD m | Survival % | |||
Year 1 | Year 2 | Year 3 | Year 5 | ||||||
Bosentan | Orally | Hughes [22] | 47 | II–IV | 291±116 | 96 | 90 | NA | NA |
Bosentan | Orally | Seyfarth [15] | 12 | III | 319±85 | 100 | 100 | NA | NA |
Epoprostenol | i.v. | Cabrol [6] | 27 | III–IV | 265±117 | 73 | 59 | 41 | NA |
Treprostinil | Subcutaneously | Skoro-Sajer [7] | 25 | III–IV | 260±111 | 80 | 80 | 80 | 53 |
Medical# | Suntharalingam [23] | 35 | NA | NA | 77 | NA | 53 | NA | |
Medical¶ | Condliffe [20] | 148 | II–IV | 239±133 | 82 | NA | 75 | 55 | |
Medical+ | Simonneau [21] | 275 | II–IV | 315 | 88 | 79 | 70 | NA |
Data are presented as mean±sd, unless otherwise stated. NYHA-FC: New York Heart Association functional class; 6MWD: 6-min walking distance; NA: not available. #: 68% received medical treatment; ¶: 86% received medical treatment; +: 61% received medical treatment.