Table 1. The World Health Organization histopathological classification of thymic epithelial tumours.
Type | Pathological features | Invasiveness % | 10-yr disease-free survival % |
A | Spindle or polygonal cell lacking atypia | 10–40 | 100 |
Resembles medullary thymoma with paucity of immature thymocytes | |||
AB | Mixed pattern of type A (lymphocyte-poor) and type B (lymphocyte-rich) thymoma | 30–40 | 100 |
Immature and mature lymphocytes | |||
B1 | Thymoma resembling the cortical thymus | 45–50 | |
B2 | Subtypes B1, B2 and B3 differentiated by an increasing epithelial/lymphocyte ratio and the emergence of atypia | 65–70 | 85 |
B3 | Mature lymphocytes | 85–90 | 35 |
Thymic carcinoma | Epithelial cell atypia | 90–95 | 15 |
Infiltration | |||
Absence of immature lymphocytes | |||
Frequent expression of CD5/KIT |
Adapted from [3].