FIG 4.

Core phylogeny of emm75 sequence type ST49 lineage associated with four reduced-susceptibility PBP2x variant types (all 111 characterized). Figure depicts tight phylogenetic clusters of emm75/PBP2x10 collected during multiple years, with highest incidence in Minnesota and more recently emerged emm75/PBP2x20 within Colorado and New Mexico. Legends for this and all other phylogenies depicted employ same scheme as follows: innermost circle is color coded for PBP2x substitution, the second circle from inside is depicting state, and the third circle from inside is depicting year of isolation.