TABLE 2.

MICs as estimated by the model

Secondary parameter	Unit	Data for:
		mcr-negative E. coli isolates			mcr-1-positive E. coli isolates			mcr-3-positive E. coli isolates
		219	12241	N100	13846	120h_B3_5	73h_B6_2	2013_SQ352
MIC (as measured)	mg/L	0.125	0.25	0.125	2	2.4	3.2	2.4
MIC for subpopulation S1 (as calculated from the modela)	mg/L	0.041	0.076	0.042	2.096	1.940	2.566	2.304
MIC for subpopulation S2 (as calculated from the modelb)	mg/L	0.136	0.342	0.137	1.751	2.495	3.051	2.430
Ratio of MICs of subpopulation S2 (calculated/measured)		1.09	1.37	1.10	0.88	1.04	0.95	1.01
Calculated fold difference of S2/S1		3.32	4.5	2.98	0.86	1.29	1.19	1.05

^aMIC calculated based on (https://rvc-repository.worktribe.com/output/1567805/supplementary-data-quantitative-pharmacodynamic-characterization-of-resistance-vs-heteroresistance-of-colistin-in-e-coli-using-a-semi-mechanistic-modelling-of-killing-curves) (equation 13 or 14) with a standard inoculum of 5 × 10⁵ CFU/mL (46).

^bMIC, MIC calculated based on (https://rvc-repository.worktribe.com/output/1567805/supplementary-data-quantitative-pharmacodynamic-characterization-of-resistance-vs-heteroresistance-of-colistin-in-e-coli-using-a-semi-mechanistic-modelling-of-killing-curves) (equation 12) with a standard inoculum of 5 × 10⁵ CFU/mL (46).