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Macitentan as part of combination therapy significantly reduced the risk of morbidity/mortality events (composite primary end-point) versus placebo in incident and prevalent pulmonary arterial hypertension (PAH) patients. Kaplan–Meier curves for PAH patients receiving background PAH-specific therapy at baseline. HR: hazard ratio. #: log rank. Reproduced and modified from [8] with permission from the publisher.
