FIG 8.

NAC decreases MDR M. tuberculosis survival in mice when combined with moxifloxacin. (A) Experimental protocol. (B and C) Bacterial CFU were enumerated from lungs and spleen at the indicated times. P was determined by unpaired two-tailed Student's t test relative to vehicle control treatment (**, P ≤ 0.01; ***, P ≤ 0.001; ns, not significant). Statistical significance between moxifloxacin (MOXI) alone and MOXI + NAC treatment is also shown (#, P < 0.05; ##, P ≤ 0.01). Error bars represent standard deviations from the mean of bacterial burden in 5 mice per group.