TABLE 1.
N-acetyl cysteine decreases recovery of M. tuberculosis-resistant mutants in infected BALB/c mice
| Treatment | No. (%) of mice |
No. of resistant colonies |
||
|---|---|---|---|---|
| Total | Harboring resistant colonies | Total/group | Avg/mousea | |
| UTb | 6 | 1 (17) | 1 | 0.17 |
| NACc | 6 | 2 (33) | 2 | 0.33 |
| MOXId | 6 | 4 (67) | 8 | 1.33 |
| NAC + MOXI | 6 | 1 (17) | 1 | 0.17 |
Total number of resistant colonies in a treatment group divided by total number of mice in that group.
UT, untreated (mice were given water [vehicle control]).
NAC (500 mg/kg body weight) was given once daily for a period of 2 weeks by oral gavage.
Moxifloxacin (MOXI; 50 mg/kg body weight) was given once daily for a period of 2 weeks by oral gavage.