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. 2022 Aug 17;66(9):e00592-22. doi: 10.1128/aac.00592-22

TABLE 1.

N-acetyl cysteine decreases recovery of M. tuberculosis-resistant mutants in infected BALB/c mice

Treatment No. (%) of mice
No. of resistant colonies
Total Harboring resistant colonies Total/group Avg/mousea
UTb 6 1 (17) 1 0.17
NACc 6 2 (33) 2 0.33
MOXId 6 4 (67) 8 1.33
NAC + MOXI 6 1 (17) 1 0.17
a

Total number of resistant colonies in a treatment group divided by total number of mice in that group.

b

UT, untreated (mice were given water [vehicle control]).

c

NAC (500 mg/kg body weight) was given once daily for a period of 2 weeks by oral gavage.

d

Moxifloxacin (MOXI; 50 mg/kg body weight) was given once daily for a period of 2 weeks by oral gavage.