FIG 1.
Ceftaroline structural popPK model. V1, volume of the central compartment; V2, peripheral volume of distribution; V3, volume of the muscle tissue compartment; V4, volume of the subcutaneous tissue compartment; CL, clearance from the central compartment; CLEVD, elimination of ceftaroline from the CSF via an external ventricular drain; Q2, intercompartmental clearance between the central and peripheral compartments; Qin, intercompartmental clearance into the tissue; Qout, intercompartmental clearance out of the tissue.