TABLE 2.
Parameter estimates of the final ceftaroline population pharmacokinetic modela
| Parameter | Estimated value (% RSE) | Bootstrap mean estimated value (95% CI)b | % CV for IIV (% RSE) | Bootstrap mean % CV (95% CI)a |
|---|---|---|---|---|
| CL (L/h) | 12.8 (4.3) | 12.75 (11.73 to 13.86) | 18.4 (16.4) | 17.5 (12.3 to 22.0) |
| V1 (L) | 18.0 (5.9) | 17.97 (15.83 to 20.03) | 16.3 (26.2) | 14.8 (7.3 to 20.4) |
| Q2 (L/h) | 4.57 (5.5) | 4.47 (3.31 to 6.67) | ||
| V2 (L) | 8.11 (11.3) | 7.93 (5.69 to 9.72) | ||
| Qin,muscle (L/h) | 5.96 (13.2) | 5.99 (4.63 to 7.77) | 30 (22) | 28.9 (15.6 to 40.6) |
| Qout,muscle (L/h) | 11.4 (9.1) | 11.35 (9.32 to 13.96) | ||
| Vmuscle (L) | 3.91 fix | 3.91 (3.91 to 3.91) | ||
| Qin,subcutaneous (L/h) | 3.3 (13.5) | 3.34 (2.41 to 4.58) | 33.3 (21.6) | 31.7 (18.5 to 39.9) |
| Qout,subcutaneous (L/h) | 5.69 (8.7) | 5.71 (4.38 to 7.32) | ||
| Vsubcutaneous (L) | 2.29 fix | 2.29 (2.29 to 2.29) | ||
| Qin,CSF (mL/h) | 1.42 (23.3) | 1.48 (0.90 to 2.39) | 57.6 (30.6) | 59.1 (20.6 to 95.9) |
| Qout,CSF (mL/h) | 16.3 (22.2) | 16.39 (9.42 to 24.60) | 57.6 (30.6) | 59.1 (20.6 to 95.9) |
| VCSF (L) | 0.15 fix | 0.15 (0.15 to 0.15) | ||
| θhealthy status | 0.481 (30.1) | 0.529 (0.117 to 0.978) | ||
| θwt | 0.012 (28.3) | 0.0123 (0.0045 to 0.0195) | ||
| θCrCL | 0.00495 (26.1) | 0.00511 (0.0031 to 0.0080) | ||
| θglucose | −0.737 (15.7) | −0.803 (−1.61 to −0.413) | ||
| Plasma additive error (mg/L) | 0.155 (4.4) | 0.151 (0.123 to 0.176) | ||
| Muscle additive error (mg/L) | 0.318 (4.3) | 0.315 (0.270 to 0.360) | ||
| Subcutaneous tissue additive error (mg/L) | 0.324 (4.4) | 0.322 (0.283 to 0.364) | ||
| CSF additive error (mg/L) | 0.518 (10.7) | 0.486 (0.266 to 0.754) |
a
CL, clearance; V1, central volume of distribution; Q2, intercompartmental clearance from the central compartment to the peripheral compartment; V2, peripheral volume of distribution; Qin, intercompartmental clearance from the central compartment to the indicated tissue; Qout, intercompartmental clearance from the indicated tissue compartment to the central compartment; fix, fixed value; RSE, relative standard error; CV, coefficient of variation; CI, confidence interval; theta symbol, estimated theta for the covariate; CrCL, creatinine clearance; wt, weight.
b
Bootstrap analysis was performed with 1,000 data sets, with 940 successful runs.