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Antibiotic susceptibility of mmpL5 loss-of-function and gain-of-function strains. Dose-response curves (mean ± s.e.m., n = 3 replicates) for the indicated Mtb strains. Results are representative of two independent experiments. The Tyr300Stop mutant (blue) harbors an empty version of the mmpS5/L5 complementation vector (30).
