TABLE 1.

Susceptibility (IC₅₀) of rv0678 mutants to 16 antibiotics^a

Antibiotic	Target process	Wild-type	rv0678 138insG	rv0678 274insA	rv0678 C268T	IC50 ratiob
PBTZ169	Arabinogalactan	1.7	6.6	7.1	4.1	4.2
BTZ043	Arabinogalactan	2.9	7.7	7.8	5	2.7
Bedaquiline	ATP synthase	330	2700	2600	2100	7.9
Clofazimine	Respiration	900	5400	4700	4000	5.2
Rifampicin	Transcription	3.9	3.9	4	3.9	1.0
Isoniazid	Mycolic acid	120	120	120	120	1.0
TCA-1	Arabinogalactan	480	610	630	570	1.3
IN-2	Arabinogalactan	730	770	780	760	1.1
Ethambutol	Arabinogalactan	2400	2800	3200	3100	1.3
Levofloxacin	DNA replication	700	700	700	690	1.0
Pretomanid	Mycolic acid	360	400	430	440	1.2
Linezolid	Translation	1300	1400	1300	1200	1.0
Streptomycin	Translation	420	410	430	440	1.0
Amikacin	Translation	930	900	950	980	1.0
Capreomycin	Translation	1200	1200	1200	1200	1.0
Fusidic Acid	Translation	4200	26000	26000	17000	6.2

^aIC₅₀ values reflect drug concentrations in nanomolar (nM).

^bThe IC₅₀ ratio was calculated by dividing the IC₅₀ for the rv0678 274insA mutant by the IC₅₀ for the wild-type strain.