TABLE 2.

Population PK estimates for the final model and bootstrap results

Parametera	Base model estimate (RSE [%]) [shrinkage [%]]	Final model estimate (RSE [%]) [shrinkage [%]]	Bootstrap median (95% CI)b
Fixed effects
${\theta }_{{\mathrm{CL}}_{\mathrm{body}\hspace{0.17em}\left(\mathrm{non}-\mathrm{trauma}\right)}}$ (L/h)	3.02 (7.4)	3.03 (7.4)	2.99 (2.57–3.50)
${\theta }_{{\mathrm{CL}}_{\mathrm{body}\hspace{0.17em}\left(\mathrm{trauma}\right)}}$ (L/h)		62.9 fixed
${\theta }_{V_1}$ (L)	14.1 (8.1)	14.2 (7.9)	14.3 (12.04–17.58)
${\theta }_Q$ (L/h)	16.2 (22.7)	15.9 (21.3)	15.1 (6.16–25.92)
${\theta }_{V_2}$ (L)	14 (8.0)	14.6 (8.1)	15.5 (12.32–19.01)
IIV
${\eta }_{{\mathrm{CL}}_{\mathrm{body}}}$ (CV [%])	59.3 (18.6) [13.2]	69.9 (19.7) [10.4]	71.1 (55.6–91.6)
${\eta }_{V_1}$ (CV [%])	41.6 (20.9) [19.2]	39.7 (16.9) [21.2]	41.6 (32.4–60.2)
${\eta }_{V_2}$ (CV [%])	32.9 (38.3) [51.3]	39.7 [52.7]	41.6
Residual variability
Proportional error (CV [%])	15.0 (28) [12.3]	15.3 (31.4) [13.1]	15.9 (10.0–21.9)
Additive error (mg/L)	2.45 (49.8) [12.3]	2.0 (75.0) [13.1]	1.56 (0.09–5.24)

^a${\theta }_{{\mathrm{CL}}_{\mathrm{body}\hspace{0.17em}\left(\mathrm{non}-\mathrm{trauma}\right)}}$, typical value of endogenous clearance in non-trauma patients; ${\theta }_{{\mathrm{CL}}_{\mathrm{body}\hspace{0.17em}\left(\mathrm{trauma}\right)}}$, typical value of endogenous clearance in trauma patients; ${\theta }_{V_1}$, typical V₁ value; ${\theta }_Q$, typical Q value; ${\theta }_{V_2}$, typical V₂ value; CV, coefficient of variation, calculated according to $\mathrm{CV}(\%)=\sqrt{\exp \left({\omega }^2\right)\hspace{0.17em}-\hspace{0.17em}1}\times 100\%$, where ${\omega }^2$ is the variance of IIV.

^bCI, confidence interval.