TABLE 3.

Risk of toxicity for different meropenem dosing regimens in non-trauma patients with different CRRT doses

Infusion type and dosing regimen	Risk of toxicity (%) with CRRT dose of:
	25 mL/h/kg	35 mL/h/kg	50 mL/h/kg
Short-term infusion (30 min)
0.5 g q6h	0	0	0
1 g q6h	7.03	0.78	0
2 g q6h	57.36	44.34	21.58
0.5 g q8h	0	0	0
1 g q8h	0.36	0	0
2 g q8h	26.38	11.94	0.9
0.5 g q8h	0	0	0
1 g q12h	0	0	0
2 g q12h	1.95	0.04	0
Prolonged infusion (3 h)
1 g q8h	0.39	0	0
2 g q8h	26.81	14.59	0.84
1 g q12h	0	0	0
2 g q12h	1.96	0	0
Continuous infusion
2 g q24h	0	0	0
3 g q24h	0.72	0	0
4 g q24h	12.70	3.57	0
6 g q24h	56.65	43.82	20.09