TABLE 1.

Significant drug-drug interactions with maribavir^a

Drug class/drug name	Interaction effect	Recommendation for administration with maribavir
Antiarrhythmics
Digoxin	Increased digoxin concnc	Co-administer with maribavir with caution. Monitor digoxin levels while on maribavir treatment
Antiepileptics
Carbemazepine	Decreased maribavir concn	Increase maribavir dose to 800 mg twice daily
Phenytoin	Decreased maribavir concn	Increase maribavir dose to 1,200 mg twice daily
Phenobarbital	Decreased maribavir concn	Increase maribavir dose to 1,200 mg twice daily
Antimycobacterials
Rifabutin	Decreased maribavir concn	Avoid co-administration with maribavir
Rifampin	Decreased maribavir concn	Avoid co-administration with maribavir
Antivirals
Valganciclovir/ganciclovir	Antiviral antagonism	Avoid co-administration with maribavir
HMG-CoA reductaseb inhibitors
Rosuvastatin	Increased rosuvastatin concn	Monitor for adverse effects of rosuvastatin (ie. myopathy, rhabdomyolysis)
Immunosuppressants
Cyclosporine	Increased cyclosporine concn	Monitor immunosuppressant levels throughout maribavir treatment, especially following maribavir initiation and discontinuation
Everolimus	Increased everolimus concn
Sirolimus	Increased sirolimus concn
Tacrolimus	Increased tacrolimus concn

^aAdapted from Takeda Liventicity prescribing information (50).

^bβ-Hydroxy β-methylglutaryl-CoA reductase.

^cconcn, concentration.